文章基本信息

标题：The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome.
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作者：E P Economou ; A W Bergen ; A C Warren 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1990
卷号：87
期号：8
页码：2951-2954
DOI：10.1073/pnas.87.8.2951
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3' ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the beta-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.