文章基本信息

标题：NF-κB prevents β cell death and autoimmune diabetes in NOD mice
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作者：Sunshin Kim ; Isabelle Millet ; Hun Sik Kim 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2007
卷号：104
期号：6
页码：1913-1918
DOI：10.1073/pnas.0610690104
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Whereas NF-{kappa}B has potent antiapoptotic function in most cell types, it was reported that in pancreatic {beta} cells it serves a proapoptotic function and may contribute to the pathogenesis of autoimmune type 1 diabetes. To investigate the role of {beta} cell NF-{kappa}B in autoimmune diabetes, we produced transgenic mice expressing a nondegradable form of I{kappa}B in pancreatic {beta} cells (RIP-mI{kappa}B mice). {beta} cells of these mice were more susceptible to killing by TNF- plus IFN-{gamma} but more resistant to IL-1{beta} plus IFN-{gamma} than normal {beta} cells. Similar results were obtained with {beta} cells lacking I{kappa}B kinase {beta