文章基本信息

标题：Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae
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作者：Kyungjae Myung ; Stephanie Smith ; Richard D. Kolodner 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：45
页码：15980-15985
DOI：10.1073/pnas.0407010101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The accumulation of gross chromosomal rearrangements (GCRs) is characteristic of cancer cells. Multiple pathways that prevent GCRs, including S-phase cell cycle checkpoints, homologous recombination, telomere maintenance, suppression of de novo telomere addition, chromatin assembly, and mismatch repair, have been identified in Saccharomyces cerevisiae. However, pathways that promote the formation of GCRs are not as well understood. Of these, the de novo telomere addition pathway and nonhomologous end-joining are the best characterized. Here, we demonstrate that defects in the mitotic checkpoint and the mitotic exit network can suppress GCRs in strains containing defects that increase the GCR rate. These data suggest that functional mitotic checkpoints can play a role in the formation of genome rearrangements.
关键词：genome instability ; mutation ; spindle ; DNA damage