文章基本信息

标题：Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
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作者：Gabrielle T. Belz ; Christopher M. Smith ; Lauren Kleinert 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：23
页码：8670-8675
DOI：10.1073/pnas.0402644101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8{alpha}-CD11b- DC subset and distinct CD8{alpha}+ lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.
关键词：T lymphocyte ; influenza A virus