首页    期刊浏览 2024年12月11日 星期三
登录注册

文章基本信息

  • 标题:Complex and dynamic redistribution of NF-κB signaling intermediates in response to T cell receptor stimulation
  • 本地全文:下载
  • 作者:Brian C. Schaefer ; John W. Kappler ; Abraham Kupfer
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2004
  • 卷号:101
  • 期号:4
  • 页码:1004-1009
  • DOI:10.1073/pnas.0307858100
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The central zone of the supramolecular activation cluster (c-SMAC) is a zone of T cell receptor (TCR) enrichment that forms at a T cell/antigen-presenting cell (APC) junction in response to antigen stimulation. We demonstrate that there is a surprisingly complex relocalization process that brings PKC{theta} and Bcl10, two intermediates in TCR activation of NF-{kappa}B, to the cytoplasmic face of the c-SMAC. TCR activation causes enrichment of PKC{theta} at the c-SMAC, followed by Bcl10 relocalization to punctate cytoplasmic structures, often at sites distant from the c-SMAC. These Bcl10 structures then undergo further relocalization, becoming enriched at the c-SMAC. TCR activation of NF-{kappa}B therefore involves the dynamic relocalization of multiple signaling intermediates, with distinct phases proximal to and distant from the c-SMAC.
国家哲学社会科学文献中心版权所有