文章基本信息

标题：Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2
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作者：Rebecca Elsaesser ; Deepak Kalra ; Ruoxia Li 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：10
页码：4740-4745
DOI：10.1073/pnas.0906386107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Photoreceptor cells are remarkable in their ability to adjust their sensitivity to light over a wide range of intensities. Rapid termination of the photoresponse is achieved in part by shuttling proteins in and out of the light-transducing compartment of the photoreceptor cells. One protein that undergoes light-dependent translocation is the rhodopsin regulatory protein arrestin. However, the mechanisms coupling rhodopsin to arrestin movement are poorly understood. Here we show that light-dependent shuttling of the major arrestin in Drosophila photoreceptor cells, Arrestin2 (Arr2), occurs independently of known elements of the phototransduction cascade. Disruptions of the trimeric G protein, phospholipase C{beta
关键词：adaptation ; photoreceptor cell ; phototransduction rhodopsin ; small GTPase