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标题：Effect of a single dose of pregabalin on herpes zoster pain
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作者：Christina Jensen-Dahm ; Michael C Rowbotham ; Haatem Reda 等
期刊名称：Trials
印刷版ISSN：1745-6215
电子版ISSN：1745-6215
出版年度：2011
卷号：12
期号：1
页码：55
DOI：10.1186/1745-6215-12-55
语种：English
出版社：BioMed Central
摘要：The effect of pregabalin on acute herpes zoster pain has not been previously evaluated. In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster. Over 6 hours of observation, pain decreased by a mean of 33% with pregabalin and 14% with placebo (p < 0.10). Effects on allodynia and SF-MPQ were not significant. Compared to an earlier study of gabapentin 900 mg for acute zoster pain and allodynia that followed a nearly identical protocol, pregabalin had a similar effect on pain and was well tolerated, with no difference from placebo on sleepiness. Common side effects of light-headedness, unsteady gait, and slowed thinking were almost identical to that observed in the earlier study of gabapentin. Subject recruitment proved difficult in part due to the widespread off-label use of gabapentin and pregabalin for acute zoster pain in our region of the USA. ClinicalTrials.gov Identifier: NCT00352651
关键词：Gabapentin ; Herpes Zoster ; Pregabalin ; Oxycodone ; Post Herpetic Neuralgia