文章基本信息

标题：Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
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作者：Steffen Desch ; Ingo Eitel ; Suzanne de Waha 等
期刊名称：Trials
印刷版ISSN：1745-6215
电子版ISSN：1745-6215
出版年度：2011
卷号：12
期号：1
页码：204
DOI：10.1186/1745-6215-12-204
语种：English
出版社：BioMed Central
摘要：Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented.
关键词：Myocardial infarction ; surrogate endpoints ; cardiac magnetic resonance imaging ; validity ; reliability ; clinical trial