文章基本信息

标题：The ability of cancer-specific and generic preference-based instruments to discriminate across clinical and self-reported measures of cancer severities
本地全文：下载
作者：Paulos Teckle ; Stuart Peacock ; Helen McTaggart-Cowan 等
期刊名称：Health and Quality of Life Outcomes
印刷版ISSN：1477-7525
电子版ISSN：1477-7525
出版年度：2011
卷号：9
期号：1
页码：106
DOI：10.1186/1477-7525-9-106
语种：English
出版社：BioMed Central
摘要：To evaluate the validity of cancer-specific and generic preference-based instruments to discriminate across different measures of cancer severities. Patients with breast (n = 66), colorectal (n = 57), and lung (n = 61) cancer completed the EORTC QLQ-C30 and the FACT-G, as well as three generic instruments: the EQ-5D, the SF-6D, and the HUI2/3. Disease severity was quantified using cancer stage, Eastern Cooperative Oncology Group Performance Status (ECOG-PS) score, and self-reported health status. Comparative analyses confirmed the multi-dimensional conceptualization of the instruments in terms of construct and convergent validity. In general, the instruments were able to discriminate across severity measures. The instruments demonstrated moderate to strong correlation with each other (r = 0.37-0.73). Not all of the measures could discriminate between different groups of disease severity: the EQ-5D and SF-6D were less discriminative than the HUI2/3 and the cancer-specific instruments. The cancer-specific and generic preference-based instruments demonstrated to be valid in discriminating across levels of ECOG-PS scores and self-reported health states. However, the usefulness of the generic instruments may be limited if they are not able to detect small changes in health status within cancer patients. This raises concerns regarding the appropriateness of these instruments when comparing different cancer treatments within an economic evaluation framework.
关键词：Quality of life ; cancer-specific instruments ; generic instruments ; external validity: responsiveness ; disease severity ; utilities