As one important professional base course in the electric information specialty, the course of “high frequency electronic circuit” has strong theoretical characteristic and abstract content. To enhance the teaching quality of this course, the computer simulation technology based on Multisim is introduced into the teaching of “high frequency electronic circuit”, which could not only deepen students’ understanding and memory of basic concepts, but also effectively help students to understand and grasp the principle of the high frequency circuit by the circuit design module and the simulation analysis function. The teaching application effect of the high frequency class C power amplifier has also proved that the Multisim software could realize the organic combination of theory and practice, and it is the profitable supplement of the traditional teaching mode.