文章基本信息

标题：A multi-scale model of erythropoiesis
本地全文：下载
作者：I. Demin ; F. Crauste ; O. Gandrillon 等
期刊名称：Journal of Biological Dynamics
印刷版ISSN：1751-3758
电子版ISSN：1751-3766
出版年度：2010
卷号：4
期号：1
页码：59-70
DOI：10.1080/17513750902777642
出版社：Taylor & Francis
摘要：In this paper, a multi-scale mathematical model of erythropoiesis is proposed in which erythroid progenitors are supposed to be able to self-renew. Three cellular processes control erythropoiesis: self-renewal, differentiation and apoptosis. We describe these processes and regulatory networks that govern them. Two proteins (ERK and Fas) are considered as the basic proteins participating in this regulation. All erythroid progenitors are divided into several sub-populations depending on their maturity level. Feedback regulations by erythropoietin, glucocorticoids and Fas ligand (FasL) are introduced in the model. The model consists of a system of ordinary differential equations describing intracellular protein concentration evolution and cell population dynamics. We study steady states and their stability. We carry out computer simulations of an anaemia situation and analyse the results.
关键词：erythropoiesis; multi-scale model; self-renewal; differentiation; bistability