文章基本信息

标题：Optimal control of a rabies epidemic model with a birth pulse
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作者：Tim Clayton ; Scott Duke-Sylvester ; Louis J. Gross 等
期刊名称：Journal of Biological Dynamics
印刷版ISSN：1751-3758
电子版ISSN：1751-3766
出版年度：2010
卷号：4
期号：1
页码：43-58
DOI：10.1080/17513750902935216
出版社：Taylor & Francis
摘要：A system of ordinary differential equations describes the population dynamics of a rabies epidemic in raccoons. The model accounts for the dynamics of a vaccine, including loss of vaccine due to animal consumption and loss from factors other than racoon uptake. A control method to reduce the spread of disease is introduced through temporal distribution of vaccine packets. This work incorporates the effect of the seasonal birth pulse in the racoon population and the attendant increase in new-borns which are susceptible to the diseases, analysing the impact of the timing and length of this pulse on the optimal distribution of vaccine packets. The optimization criterion is to minimize the number of infected raccoons while minimizing the cost of distributing the vaccine. Using an optimal control setting, numerical results illustrate strategies for distributing the vaccine depending on the timing of the infection outbreak with respect to the birth pulse.
关键词：rabies epidemic model; vaccine; optimal control; ordinary differential equations