The goal of this paper was to review studies about markers and predictors of conjugality construction and dissolution from a systemic perspective, emphasizing the implications for couples’ therapy. PsycINFO and SciELO databases were consulted, with the following keywords (in different combinations of Portuguese and English): literature review, couples’ therapy, conjugality, conjugality dissolution, predictors, and markers. We consulted 132 studies published until August 2009. Conjugal satisfaction is pointed out as the main concept, marker and predictor involved in both the construction and maintenance of conjugality. Models describing divorce as a complex and long process are presented, emphasizing those non-linear models may improve the possibility of prediction of conjugal dissolution, based on psychosocial factors. We conclude that interactional studies bring important contributions to couples’ therapy in suggesting directions and interventions. However, the simple use of markers and predictors as variables in therapeutic models has not been improving therapeutic efficacy, because these are only indicators of certain ongoing patterns. Thus, predictors and markers would be better understood as indicating systemic processes of stability and change.