文章基本信息

标题：Isoprostani e stress ossidativo nel danno cerebrale del neonato
本地全文：下载
作者：Luisa MINGHETTI ; Antonietta BERNARDO e Anita GRECO
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2001
卷号：37
期号：04
出版社：Editrice Kurtis Srl
摘要：Summary (Isoprostanes and oxidative stress in brain damage of the newborn). - Isoprostanes are a family of biologically active molecules recently characterized, which is emerging as a new class of specific and reliable markers of in vivo and ex vivo lipid peroxidation and oxidative damage. These molecules are stable, relatively abundant and easily detectable by sensitive and specific analytical methods. In the last years, the measurement of their levels in tissue homogenates or biological fluids has significantly improved our knowledge on the involvement of oxidative stress in several neurological diseases. Here we present evidence indicating that isoprostanes can be successfully used also to study the mechanisms involved in free radical brain damage following hypoxic-ischaemic or inflammatory conditions in newborns and preterm infants.
关键词：Key words: isoprostanes, brain damage, free radicals, oligodendrocytes.