文章基本信息

标题：I simbionti batterici (Wolbachia) delle filarie: implicazioni per il trattamento e la patologia delle filariosi
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作者：Chiara BAZZOCCHI (a) ; Fabrizio CECILIANI (b) e Norbert BRATTIG (c)
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2001
卷号：37
期号：02
出版社：Editrice Kurtis Srl
摘要：Summary (The Wolbachia endosymbionts of filarial nematodes: implications for the treatment and pathogenesis of filarial diseases). - Filarial nematodes harbour intracellular, Gram-negative bacteria belonging to the genus Wolbachia. These bacteria have been observed in various species of filariae, including the main filariasis agents of humans and animals. It has been suggested that Wolbachia could play an important role in the biology of filarial nematodes and could be implicated in the pathogenesis of filarial diseases. Wolbachia could thus represent a target for the control of filariasis and a key to the understanding of these diseases. Indeed, in various species of filariae, tetracycline treatments have been shown both to reduce/eliminate the Wolbachia population and to determine detrimental effects on the nematodes. In addition, proteins of Wolbachia have been shown to determine specific IgG responses in animals infected by filariae and some Wolbachia molecules (e.g. LPS) have been shown to stimulate innate-immunity responses (e.g. production of cytokines such as IL1, IL6, IL10, TNF-α and IFN-γ by macrophages)
关键词：Key words: Wolbachia, filariasis, cytokine, innate immunity, pathogenesis.