文章基本信息

标题：MDMA (ecstasy): aspetti neuroendocrini e comportamentali
本地全文：下载
作者：Gilberto GERRA (a) ; Amir ZAIMOVIC (a) ; Gabriele MOI (a) 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2002
卷号：38
期号：03
出版社：Editrice Kurtis Srl
摘要：Summary (MDMA (ecstasy): neuroendocrine and behavioural effects). - Long lasting 5HT system impairment has been demonstrated in experimental animals exposed to ecstasy use; MDMA seems to be able to induce behavioral conditioning and reiterated use because of its dopaminergic action. Among behavioral aspects of ecstasy users mood disorders, irritability and difficult in relationships, interpersonal difficulties, high levels of impulsiveness and hostility, high sensation seeking, cognitive and attentive deficit have been reported. A derangement of serotonin system function was reported also in humans exposed to ecstasy, as confirmed by neuroendocrine challenges and brain imaging techniques. Recent researches suggest functional changes in dopaminergic system too. The persistence of behavioral and neuroendocrine changes many months after MDMA’s discontinuation, indicate a lack of reversibility in the dysfunction induced by ecstasy, or the persistence of psychobiological traits that could preexist to MDMA exposure, possibly involved in substance abuse vulnerability.
关键词：Key words: MDMA, psychobiological traits, individual vulnerability, serotonin, dopamine, behaviour.