文章基本信息

标题：Microwave-assisted Efficient Synthesis of Isatins and spiro -Thiadiazolines under Green Chemistry Protocol
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作者：M. M. Hossain ; M. A. Foysal ; M. Mahabub 等
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2010
卷号：2
期号：02
页码：322-329
DOI：10.3329/jsr.v2i2.3731
出版社：Rajshahi University
摘要：
MW-assisted treatment of oximinoacetanilides obtained from substituted primary aromatic amines was carried out in conc. H₂SO₄ medium for 5-10 sec to give cyclic amides (isatins) through intramolecular cyclization by means of electrophilic aromatic substitution. Isatins reacted with thiosemicarbazide under MW-condition gave the corresponding Schiff-bases. The Schiff-bases undergo cyclization in presence of minimal Ac₂O under MW-irradiation for 3-4 min to give the spiro -thiadiazoline acetyl derivatives in excellent yield.

Keywords : Microwave-synthesis; Isatins; Schiff-base; spiro -Thiadiazoline; Green chemistry.

© 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

DOI: 10.3329/jsr.v2i2.3731 J. Sci. Res. 2 (2), 322-329 (2010)
关键词：Green chemistry.