Simultaneous occurrence of adenocarcinoma and neuroendocrine carcinoma is rare in tumours
of gastrointestinal tract, but even rarer in tumours of the gall bladder. We report a similar case
in 57 year male admitted with pain in abdomen, intermittent jaundice, and loose motions since
1 year. Per abdomen examination revealed a palpable mass in the right hypochondriac region.
C T scan revealed a distended gall bladder with mildly enhancing lobulated, polypoidal mass in
fundal region. Gross examination of the specimen revealed enlarged gall bladder with a lobulated,
polypoidal, fundic mass measuring 4 cm in diameter. On cut surface it, was greyish white
to yellow infiltrating the wall to reach serosa. revealed a tumour showing glandular (adenocarcinoma)
and neuroendocrine differentiation. Immunohistochemical stains were positive for
both glandular and neuroendocrine elements. Malignant tumours of the gall bladder are uncommon
with mixed tumours being even rarer. The histogenesis of composite gastrointestinal
tumours is not clear