文章基本信息

标题：Dopamine Suppresses Octopamine Signaling in C. Elegans: Possible Involvement of Dopamine in the Regulation of Life
本地全文：下载
作者：Satoshi Suo ; Joseph G. Culotti ; Hubert H. M. Van Tol 等
期刊名称：Aging
出版年度：2009
卷号：01
期号：10
出版社：U.S.Department of Health & Human Service
摘要：Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food deprivation-mediated lifespan extension. We have shown recently that dopamine signaling, activated by the tactile perception of food, suppresses octopamine signaling and that the cessation of dopamine signaling in the absence of food leads to activation of octopamine signaling. Here, we discuss the apparent conservation of neural and molecular mechanisms for dopamine regulation of octopamine/noradrenaline signaling and a possible role for dopamine in lifespan regulation.
关键词：dopamine; octopamine; serotonin; food; lifespan; CREB