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标题：Role of NFκB in Age-related Vascular Endothelial Dysfunction in Humans
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作者：Anthony J. Donato ; Gary L. Pierce ; Lisa A. Lesniewski 等
期刊名称：Aging
出版年度：2009
卷号：01
期号：08
出版社：U.S.Department of Health & Human Service
摘要：Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the United States and other industrialized societies. Older age is the major risk factor for development of CVD [1]. Emerging evidence over the past 20 years suggests that the arterial vascular endothelium plays a critical role in the development of CVD, most notably, atherosclerosis. A healthy vascular endothelium is characterized by a tightly regulated balance of pro- and anti-oxidants, vasodilators and vasoconstrictors, and pro- and anti-inflammatory molecules. A diseased or dysfunctional endothelium displays a “pro-atherogenic” phenotype, losing its tightly regulated balance and adopting a pro-oxidant/vasoconstrictor/pro-inflammatory phenotype. A hallmark of arterial endothelial dysfunction is impaired endothelial dependent dilation, which is predictive of future CVD events [1, 2].
关键词：aging; endothelial dysfunction; NFkB; oxidative stress; inflammation