文章基本信息

标题：Human Insulin/IGF-1 and Familial Longevity at Middle Age
本地全文：下载
作者：Maarten P. Rozing ; Rudi G.J. Westendorp ; Marijke Frölich 等
期刊名称：Aging
出版年度：2009
卷号：01
期号：08
出版社：U.S.Department of Health & Human Service
摘要：Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy. Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.
关键词：familial longevity; height; glucose handling; IGF-1; IGFBP3