文章基本信息

标题：Keeping your Senescent Cells under Control
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作者：Lars Zender, K. Lenhard Rudolph
期刊名称：Aging
出版年度：2009
卷号：01
期号：05
出版社：U.S.Department of Health & Human Service
摘要：Cellular senescence is a stable form of cell-cycle arrest which is thought to limit the proliferative potential of premalignant cells [1]. The senescence phenotype was initially described by Hayflick and Moorhead in 1961 on human fibroblasts undergoing replicative exhaustion in culture [2]. It has been shown that senescence can be triggered in different cell types in response to diverse forms of cellular damage or stress [for review see 1]. Importantly, while senescence was denounced as a tissue culture phenomenon for many years, recent in vivo studies demonstrated that cellular senescence represents a potent failsafe mechanism against tumorigenesis and contributes to the cytotoxicity of certain anticancer agents [see for example 3-7]. Interestingly, senescent cells have also been observed in certain aged or damaged tissues and there is growing evidence that senescence checkpoints can affect the regenerative reserve of tissues and organismal aging [8-11]. However, senescence may also have positive effects on organ maintenance by limiting pathological responses to acute forms of injury such as fibrotic scarring in response to chemical induced liver injury [12].
关键词：Senescence associated secretory phenotype; SASP; stress signaling; Il-6; telomeres; oncogene induced senescence