文章基本信息

标题：Adaptation, Aging, and Genomic Information
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作者：Michael R. Rose
期刊名称：Aging
出版年度：2009
卷号：01
期号：05
出版社：U.S.Department of Health & Human Service
摘要：Aging is not simply an accumulation of damage or inappropriate higher-order signaling, though it does secondarily involve both of these subsidiary mechanisms. Rather, aging occurs because of the extensive absence of adaptive genomic information required for survival to, and function at, later adult ages, due to the declining forces of natural selection during adult life. This absence of information then secondarily leads to misallocations and damage at every level of biological organization. But the primary problem is a failure of adaptation at later ages. Contemporary proposals concerning means by which human aging can be ended or cured which are based on simple signaling or damage theories will thus reliably fail. Strategies based on reverse-engineering age-extended adaptation using experimental evolution and genomics offer the prospect of systematically greater success.
关键词：Aging; adaptation; forces of natural selection; Hamiltonian research; experimental evolution