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文章基本信息

  • 标题:Nonparametric Multiple Imputation of Left Censored Event Times in Analysis of Follow-up Data
  • 本地全文:下载
  • 作者:Juha Karvanen ; Olli Saarela ; Kari Kuulasmaa
  • 期刊名称:Journal of Data Science
  • 印刷版ISSN:1680-743X
  • 电子版ISSN:1683-8602
  • 出版年度:2010
  • 卷号:8
  • 期号:1
  • 页码:151-172
  • 出版社:Tingmao Publish Company
  • 摘要:

    In this paper, we consider analysis of follow-up data where each event time is either right censored, observed, left censored or left truncated. In the case of left censoring, the covariates measured at baseline are considered as missing. The work is motivated by data from the MORGAM Project, which explores the association between cardiovascular diseases and their classic and genetic risk factors. We propose a nonparametric multiple imputation (NPMI) approach where the left censored event times and the missing covariates are imputed in hot deck manner. The left truncation due to deaths prior to baseline is compensated by Lexis diagram imputation introduced in the paper. After imputation, the standard estimation methods for right censored survival data can be directly applied. The performance of the proposed imputation approach is studied with simulated and real world data. The results suggest that the NPMI is a flexible and reliable approach to the analysis of left and right censored data.

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