文章基本信息

标题：Homology Modelling of Hypoxanthin–Guanine Phosphoribosyltransferase, Enzyme Involved in Salvage Pathway of Purine Metabolism
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作者：Jyotsna Choubey ; Ashish Patel ; Sheetal Khatri 等
期刊名称：Journal of Computer Science & Systems Biology
印刷版ISSN：0974-7230
出版年度：2009
卷号：2
期号：5
页码：259-261
出版社：OMICS Publishing Group
摘要：Hypoxanthin-guanine phosphoribosyltransferase (HPRT) is responsible for catalyzing a reaction which breaks down uric acid in the body. The lack of this enzyme creates a build-up of uric-acid, leading to a neurological problem, joint pain and kidney problem. The condition is called Lesch-Nyhan Syndrome. A comparative modelling of the protein Hypoxanthin-guanine phosphoribosyltransferase is performed using the modeling program modeller9v3.The following structure validation programs PROCHECK, PROSA, VERIFY3D and WHATIF are used. Descret Optimized Protein Energy (DOPE), is a statistical potential used to asses homology model in protein structure prediction. Predicted model can be useful to develop new inhibitor against Lesch-Nyhan Syndrome. CASTp can be used to study surface features and functional regions of proteins.
关键词：Phosphoribosyltransferase ; Catalysis ; PROCHECK ; Mmodeling ; Validation ; Lesch-Nyhan Syndrome