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标题：Alterations in Lipid Peroxidation and Certain Antioxidant Enzymes in Different Age Groups under Physiological Conditions
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作者：Kuldip Singh ; Sandeep Kaur ; Kanta Kumari 等
期刊名称：Journal of Human Ecology
印刷版ISSN：0970-9274
出版年度：2009
卷号：27
期号：02
出版社：Kamla-Raj Enterprises
摘要：Free radicals and peroxides are involved in physiological phenomena such as synthesis of prostaglandin and thromboxanes and are thought to participate in aging process. Free radicals are also responsible for the pathogenesis of various diseases like atherosclerosis, inflammatory diseases and malignancies etc. The objective of the present work was to investigate the possible role of free radicals in aging process by studying age related changes in lipid peroxidation and in certain antioxidant enzymes like xanthine oxidase, superoxide dismutase, glutathione peroxidase and glutathione. The level of lipid peroxidation and antioxidant initiating enzyme xanthine oxidase and antioxidant scavenging enzymes like superoxide dismutase, glutathione peroxidase and glutathione was estimated in 300 healthy male and females ranging in age from 15 to 65 years. The level of xanthine oxidase enzyme and lipid peroxidation was significantly increased while the levels of antioxidant defense enzymes such as superoxide dismutase and glutathione peroxidase and glutathione were deceased significantly in plasma with the increase of age. Our observations are suggesting that old age is associated with an increase in systematic oxidative stress.
关键词：Alterations;Lipid Peroxidation;Antioxidant Enzymes;Age Groups;Physiological Conditions