文章基本信息

标题：QSAR Analysis of Aminoquinoline Analogues as MCH1 Receptor Antagonist
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作者：D. K. Patel, N. M. Patel
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2009
卷号：1
期号：3
页码：594-605
DOI：10.3329/jsr.v1i3.2126
出版社：Rajshahi University
摘要：Quantitative structure activity relationship (QSAR) has been established for 2-aminoquinoline-6-carboxamide melanin-concentrating hormone (MCH) 1R antagonists. The multiple linear regressions were used to generate the relationship between biological activity and calculated descriptors. From the 100 of models with r2 > 0.700 was developed. Final selected model was prepared using four descriptors (DMXC, KChiV4, Rcom, and IM1L) which are belong to topological, steric, spatial and electrotopological class descriptor. The validation of the model was done by cross validation; randomization and external test set prediction. The binding pattern of most active compound B15 was postulated based on the pharmacophoric features to further exploration of QSAR model
关键词：QSAR; MCH1 receptor; Obesity; Aminoquinline