文章基本信息

标题：CNS Activity of the Methanol Extracts of Sapindus emarginatus Vahl in Experimental Animal Models
本地全文：下载
作者：J. Srikanth, P. Muralidharan
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2009
卷号：1
期号：3
页码：583-593
DOI：10.3329/jsr.v1i3.1772
出版社：Rajshahi University
摘要：The aim of the present study is to investigate central nervous system (CNS) activity of the methanol extract of Pericarp of Sapindus emarginatus (Sapindaceae) in Swiss albino mice and Wistar albino rats. A daily dose of 100 and 200 mg/kg of the extract was administered to the animals for 15 days, after which various CNS experiments were recorded and compared with the control animals. General behavior, exploratory behavior, muscle relaxant activity cocaine induced hyperactivity and phenobarbitone sodium-induced sleeping time were studied. The results revealed that the methanol extract of Pericarp of Sapindus emarginatus at 100 and 200 mg/kg caused a significant reduction in the spontaneous activity (general behavioral profile), remarkable decrease in exploratory behavioral pattern (Y-maze and head dip test), a reduction in muscle relaxant activity (rotarod and traction tests), inhibition of cocaine induced hyperactivity and also significantly potentiated phenobarbitone sodium–induced sleeping time. The results suggest that methanol extract of Sapindus emarginatus exhibit CNS depressant activity in tested animal models
关键词：Sapindus emarginatus; Cocaine; CNS activity; Experimental animals