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标题：Chemical contaminants in drinking water: mutagenic and toxic effects
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作者：Gabriela Mancaş ; Terttu Vartiainen ; Paku Rantakokko 等
期刊名称：Journal of Preventive Medicine
印刷版ISSN：1582-5388
出版年度：2002
卷号：10
期号：3
出版社：Institute of Public Health, Iasi
摘要：This study aimed to estimate the hazards associated with the use of chlorination in a water-work where some episodes of chemical pollution were recorded in the recent years. The methodological approach consisted in twice a year sampling of large volumes of raw and chlorinated water then processed to concentrate the non-volatile organic chemicals. The analyses of water samples indicated high levels of organic matter in chlorinated water, up to 21.17g/l. A complex mixture of chemicals in each of both extracts has been identified by GC-MS technique. Higher levels of 3-chloro-4( dichloromethyl )-5-hydroxy-2(5H)- furanone (MX), a strong mutagen compound, in chlorinated water extract in comparison with the corresponding raw water extract of samples of 2000 year summer have been measured for the first time in Romania. The mutagenicity test Ames results of water extracts were in agreement with the corresponding MX levels. Acute and sub-acute experiments on young fish exposed to gradually increased concentrations of chemicals in water, for different exposure periods have indicated higher lethality percentage for exposure in chlorinated water compared with raw water. A dose-effect relationship between the concentrating factors of chemicals and the fish lethalities was also established, statistically significant for acute experiments
关键词： water chemical contamination, chlorination, effect assessment, MX, fish, experimental exposure