文章基本信息

标题：Correlation between metal ions and clinical findings in subjects affected by Alzheimer's disease
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作者：Giuseppe Bomboi ; Francesca Marchione ; Micaela Sepe-Monti 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2005
卷号：41
期号：02
页码：205-212
出版社：Editrice Kurtis Srl
摘要：There is a growing interest to evaluate metals in biological fluids in Alzheimer’s disease (AD). There are numerous studies on this theme, but just few papers analyzed the relationship between haematic metal concentrations and the clinical features of the disease. In this study, possible associations between clinical features of AD and the variations in serum and blood concentration of some metals, as well as the serum oxidative status and the antioxidant capacity have been investigated. Sixty subjects with AD were enrolled. Some elements correlated with gender, depression and duration of the disease. However, the most significant result was the relationship between blood Ca and Fe levels and the severity of cognitive impairment. We hypothesize that Ca and Fe might play an important role in the pathogenetic mechanisms of AD.
关键词：Alzheimer’s disease, metals, serum, whole blood.