文章基本信息

标题：Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease
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作者：Beatrice Bocca ; Giovanni Forte ; Francesco Petrucci 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2005
卷号：41
期号：02
页码：197-203
出版社：Editrice Kurtis Srl
摘要：The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer’s disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p ≤ 0.05) discrepancies were found: i) increment of Ca, Cd, Hg, Mg, Si and Sn, and decrement of Al, Co, Fe and Zn in serum; ii) higher concentrations of Cu, Li, Mn, Sn and Zr and lower of Fe, Hg, Mo in blood; iii) overproduction of oxidant species (SOS) and decrease of the anti-oxidant capacity (SAC) (p ≤ 0.001, for both). Variables that, joined, better discriminated between patients and controls resulted to be Si, SOS, SAC, Co, Ca, Al in serum (94% of cases correctly classified) and Cu, Zr, Mo and Fe in blood (90% of cases properly categorized).
关键词：metals, oxidative status, Alzheimer’s disease, serum, whole blood.