文章基本信息

标题：Metal ions and oxidative protein modification in neurological disease
本地全文：下载
作者：Lawrence M. Sayre ; Paula I. Moreira ; Mark A. Smith 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2005
卷号：41
期号：02
页码：143-164
出版社：Editrice Kurtis Srl
摘要：This review highlights the role of oxidative stress and imbalances in metal ion homeostasis in the neurodegenerative diseases Alzheimer’s disease and Parkinson’s disease and in the progressive demyelinating disease multiple sclerosis. The chemistry and biochemistry of oxidative stress-induced protein damage are first described, followed by the evidence for a pathological role of oxidative stress in these disease states. It is tempting to speculate that free radical oxygen chemistry contributes to pathogenesis in all these conditions, though it is as yet undetermined what types of oxidative changes occur early in the disease, and what types are secondary manifestations of neuronal degeneration.
关键词：neurodegeneration, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, metals, oxidative stress.