The American Heart Association (AHA) developed a behavioral roundtable to address cardiovascular disease (CVD) disparities, with a focus on the primary prevention of obesity. This roundtable considered the preventable differences in the indicators of health of different population groups, often defined by race, ethnicity, sex, educational level, socioeconomic status, and geographic location of residence. To reduce the rates of CVD in disproportionately affected population groups, we explored behavioral strategies for each of the 5 risk stages: 1) no known cardiovascular risk, 2) known cardiovascular risk, 3) acute CVD, 4) rehabilitation, and 5) chronic CVD. We examined sample AHA programs targeting each of the risk stages to consider how to pose questions about reach, efficacy/effectiveness, adoption, implementation, and maintenance (the RE-AIM evaluation framework). The strategies outlined in this article can be used to develop collaborations for planning, implementing, and evaluating possible interventions to reduce CVD disparities.