文章基本信息

标题：Urinary nicotine metabolites levels in teenagers
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作者：Gabriela ; Manca ş ; Marieta Vasilov 等
期刊名称：Journal of Preventive Medicine
印刷版ISSN：1582-5388
出版年度：2005
卷号：13
期号：1-2
出版社：Institute of Public Health, Iasi
摘要：The aim of this study was to investigate the relationship between the tobacco smoke exposure (assessed by questionnaire) and the urinary total nicotine metabolites in teenagers using an accessible and rapid method and, also, to validate is method using the questionnaire in relation with nicotine metabolites levels measurements. Material and methods. A sample of 296 young aged 15-20 years was randomly selected from three high schools. An adequate questionnaire for assessing their smoking status was used and urine specimens were sampled for measurement of total nicotine metabolites and creatinine levels. Adequate analytical techniques were applied for accurate comparison of the two methods for tobacco smoke exposure assessment in teenagers. Results. A smoker frequency of 40% among the investigated teenagers was self-reported, ranging from 38% in the subjects aged 15-17 years to 50% in those aged 19-20 years. Only 22% of them were self-reported unexposed and nonsmokers and 37.6 % - passive smokers. An increasing trend was found for the urinary cotinine levels according to the duration of exposure through smoking only for those teenagers self-reported to smoke daily 5-10 cigarettes. An increasing trend was established for cotinine levels according with the smoking intensity of the subjects, with statistical significant differences between different smoker categories. The urinary thiocyanate levels did not correlate with the smoking intensity. The validation of self-reported smoker status (assessed by questionnaire) in comparison with the urinary cotinine levels has indicated a sensitivity of 0.92 and a specificity of 0.49. Conclusions. The findings of our study have highlighted a linear positive correlation between the urinary cotinine levels and the number of cigarettes smoked daily and, partially, with the duration of smoking exposure of teenagers. The urinary cotinine level, as exposure bioindicator, was proved to be a useful tool for measurement of organism impregnation, as smoking consequence. The techniques of validation by the help of questionnaire have indicated that is a sensitive but less specific method for exposure assessment in the comparison with the major urinary nicotine metabolite measurement.
关键词：tobacco smoking, teenagers, urinary nicotine metabolites, validation