The calibre persistent artery or Dieulafoy’s disease of stomach is the most fatal form of upper gastrointestinal tract bleeding with mortality of around 60.5%. We are reporting a fatal case of a 37-year-old male who complained of haematemesis and was admitted in hypovolaemic shock. Endoscopy revealed stomach filled with fresh blood. On autopsy, a gaping blood vessel was found near the cardiac end and section of which showed a histologically normal, dilated and tortuous artery in the submucosa. Diagnosis of calibre persistent artery of stomach was made. It can occur in gastrointestinal as well as respiratory tract. Awareness of this condition by the endoscopist could have prevented mortality and hence it should be considered in the differential diagnosis of unexplained gastrointestinal bleeding