文章基本信息

标题：In vivo analysis of wound healing by optical methods
本地全文：下载
作者：Alborova A ; Lademann J ; Kramer A 等
期刊名称：GMS Krankenhaushygiene Interdisziplinär
印刷版ISSN：1863-5245
出版年度：2008
卷号：03
期号：01
出版社：German Medical Science GMS Publishing House, Düsseldorf
摘要：The analysis of wound healing is important for the therapy control and for the development of drugs stimulating the healing process. Wounds cause damage to the skin barrier. A damaged stratum corneum leads to an increased water loss through the skin barrier. The standard measuring procedure for characterization of wound healing is the measurement of transepidermal water loss (TEWL). The disadvantage of this method is that it can be easily disturbed by the perspiration of the volunteers and by topically applied substances, for instance wound healing creams. In the study presented, in vivo laser scanning microscopy and optical coherent tomography were compared concerning the application for their analysis of wound healing processes. The laser scanning microscopy allows the analysis of the healing process on a cellular level. The course of wound healing determined by laser scanning microscopy was correlated with numerical values, allowing the numerical characterization of the wound healing process.
关键词：in vivo laser scanning microscopy, optical coherent tomography, transepidermal water loss, suction blister technique, wound healing analysis