文章基本信息

标题：Proliferationsförderung und Biokompatibilität von Polihexanid
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作者：Wiegand C ; Abel M ; Kramer A 等
期刊名称：GMS Krankenhaushygiene Interdisziplinär
印刷版ISSN：1863-5245
出版年度：2007
卷号：02
期号：02
出版社：German Medical Science GMS Publishing House, Düsseldorf
摘要：The therapy of critically colonized or locally infected chronic wounds often demands a antiseptic treatment to ensure the removal of pathogenic micro-organisms that could lead to an infection. Therefore, wound dressings combined with antimicrobial agents such as silver, povidone-iodine or polihexanide are increasingly utilized. Polihexanide is regarded first choice for chronic wounds because of its good skin and wound tolerance beside its antimicrobial effectivity. Furthermore, it possesses the ability to induce proliferation in vitro as well as in animal models. The present study was able to show that polihexanide has a positive effect on the proliferation of human keratinocytes in concentrations up to 2 µg/ml. On the other hand, higher concentrations of polihexanide inhibit cell proliferation or were directly cytotoxic to the tested cell types in vitro.