文章基本信息

标题：Wechselwirkung von Octenidin und Chlorhexidin mit Säugerzellen und die resultierende Mikrobiozidie (Remanenzverhalten) der Reaktionsprodukte
本地全文：下载
作者：Müller G, Kramer A
期刊名称：GMS Krankenhaushygiene Interdisziplinär
印刷版ISSN：1863-5245
出版年度：2007
卷号：02
期号：02
出版社：German Medical Science GMS Publishing House, Düsseldorf
摘要：The antiseptic agents chlorhexidine digluconate (CHX) and octenidine dihydrochloride (OCT) are bound to murine fibroblasts (L929, ATCC CCL1), human epithelial cells (FL, ATCC CCL62), and primary human keratinocytes. The active agents cannot be removed by washing with phosphate buffered saline (PBS). The resulting combinations of cells and active agent are effective against the test microorganisms Escherichia coli and Staphylococcus aureus in a sustained release matter. The microbicidal activity has not inactivated by the presence of 10% fetal bovine serum (FBS). The microbicidal effect of cell-bound OCT is superior to cell-bound CHX comparing the same concentrations of active agent. Possibly, CHX is fixed more firmly at or in the cellular membrane, but not for OCT. In the presence of microorganisms OCT is released more easily from the combination cells and active agent than CHX.