文章基本信息

标题：Nutzen-Risiko-Bewertung des Einsatzes von Triclosan in chirurgischem Nahtmaterial
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作者：Kramer A ; Assadian O ; Guggenbichler JP 等
期刊名称：GMS Krankenhaushygiene Interdisziplinär
印刷版ISSN：1863-5245
出版年度：2006
卷号：01
期号：01
出版社：German Medical Science GMS Publishing House, Düsseldorf
摘要：Based on the current literature, a risk/benefit analysis of the antimicrobial impregnation of surgical sutures with triclosan is performed, focussing on efficacy and indication, risk of resistance development, toxicological characteristics, and environmental tolerance. From a toxicological point of view, there are no restrictions for triclosan-impregnated suturing materials. Environmental tolerance is also acceptable for this application area, because the amounts of triclosan involved pose no problems in terms of degradability. The use of surgical suturing material coated with triclosan is seen especially in contaminated wounds or where the risk of infection is high. In order to meet this requirement, the antimicrobial properties of triclosan are particularly emphasized. Both in vitro and in vivo, triclosan is highly effective against Staphylococcus spp., including MRSA, the pathogens most frequently involved in postoperative wound infections. Triclosan is not effective against Pseudomonas aeruginosa, Serratia marcescens and Alcaligenes spp., due to their intrinsic resistance against this agent. As long as the inducible resistance in vitro against triclosan is not clinically relevant, it does not speak against triclosan use in suturing material, especially because pure triclosan is applied only to a specific, limited area for a short time. However, because triclosan can induce in vitro the development of cross-resistances to antibiotics, the implementation of this agent must be exclusively limited to medically founded indications.