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标题：Bakteriozide Wirkung von pulsierendem Gleichstrom in vitro
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作者：Daeschlein G, Ney F, Kramer A
期刊名称：GMS Krankenhaushygiene Interdisziplinär
印刷版ISSN：1863-5245
出版年度：2006
卷号：01
期号：01
出版社：German Medical Science GMS Publishing House, Düsseldorf
摘要：The positive effect of electrical stimulation (ES) on wound healing has been shown in vitro and in vivo. Based on increased blood flow, protein denaturation and stimulation of cellular defence, an antibacterial effect of ES is to be expected. Although the antibacterial effect of ES already has been demonstrated in vitro, little attention has been paid to the direct antibacterial effect of changing polarity of the applied current. The aim of this study was to investigate the antibacterial effect of positive and negative monophasic high voltage pulsed current (HVPV) on typical gram positive and gram negative pathogens of chronic wounds. Using the WoundEL®-System, three gram negative (E. coli, P. aeruginosa, K. pneumoniae) and three gram positive (S. aureus, S. epidermidis, E. faecium) organisms were tested against positive and negative polarity HVPV. All tested organisms were significantly (P < 0.01) reduced by ES. The reduction differed significantly (P = 0.02) between positive and negative polarity, with the highest log10 RF achieved with positive polarity. Using positive polarity, the maximum RF was measured for Escherichia coli (median log10 RF 0.83; 25th percentile 0.59, 75th percentile 0.98), the lowest for Staphylococcus epidermidis (median log10 RF 0.20; 25th percentile 0.17, 75th percentile 0.24). Yet, there was no significant difference with positive ES against gram positive (P = 0.35) or gram negative (P = 0.71) organisms.