文章基本信息

标题：Biokompatibilitätsindex silberhaltiger Wundantiseptika
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作者：Müller G, Kramer A, Karkour Y
期刊名称：GMS Krankenhaushygiene Interdisziplinär
印刷版ISSN：1863-5245
出版年度：2006
卷号：01
期号：01
出版社：German Medical Science GMS Publishing House, Düsseldorf
摘要：We defined a biocompatibility index (BI) for comparing. The BI takes into account both the results of the in-vitro cytotoxicity, i.e. the concentration at which 50% of the cells are damaged, and the microbiocidal activity, i.e. the concentration at which the baseline burden of the test micro-organisms is reduced by at least 5-log steps. For AgNO3 and Ag-SD no BI value was calculable since the highest tested active substance concentration of 1% corresponding to the concentration for use results in no reduction in the baseline bacterial burden. However, the theoretical value should be much smaller than 0.002 All tested silver-containing preparations were not effective against Staphylococcus aureus using 30 min contact time. Using Escherichia coli as test microorganisms, colloidal silver in the form of mild silver protein (based on Ag) has a BI value of 0.002, chlorhexidine 0.8, PVP-iodine (based on iodine) 1.0, polihexanide 1.5, and octenidine 1.8, i.e. the Ag-containing preparations do not act antiseptically within 30 min of contact time. Therefore, depending from the kind of the wound in clinical practice Ag-containing preparations should be substituted by e.g. polihexanide-, octenidine- or PVP-iodine-containing preparations, which show in lower concentration than in the concentration in use microbicidal effect within 30 min.