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标题：ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study
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作者：Anuurad, Erdembileg ; Lu, Guijing ; Rubin, Jill 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2007
卷号：48
期号：3
页码：693-698
DOI：10.1194/jlr.M600431-JLR200
出版社：American Society for Biochemistry and Molecular Biology
摘要：The genetic variability of apolipoprotein E (apoE) influencesplasma lipoprotein levels, and allele frequencies differ betweenAfrican Americans and Caucasians. As African Americans havehigher lipoprotein [a] (Lp[a]) levels than Caucasians, we investigatedthe effects of the apoE gene on allele-specific apolipoprotein[a] (apo[a]) levels across ethnicity. We determined apo[a] sizes,allele-specific apo[a] levels (i.e., levels associated withalleles defined by size), and the apoE gene polymorphism in231 African Americans and 336 Caucasians. African Americans,but not Caucasians, with the apo E2 genotype had lower levelsof Lp[a] compared with those with the apo E4 genotype (9.6 vs.11.2 nmol/l; P = 0.034, expressed as square root levels). Distributionof apo[a] alleles across apoE genotypes were similar betweenAfrican Americans and Caucasians. Among African Americans withlarge apo[a], the allele-specific apo[a] level was significantlylower among ${varepsilon}$ 2 carriers compared with ${varepsilon}$ 3 or ${varepsilon}$ 4 carriers (5.4 vs.6.6 and 7.4 nmol/l, respectively; P < 0.005, expressed assquare root levels). In contrast, there was no significant differencein allele-specific apo[a] levels across apoE genotypes amongCaucasians. For large apo[a] sizes, apoE genotype contributedto the observed African American-Caucasian differences in allele-specificapo[a] levels. Supplementary key words lipoprotein [a] • polymorphisms • apolipoprotein E • genetics • ethnicity • apolipoprotein [a]