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标题：Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats
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作者：Tovar, Armando R. ; Torre-Villalvazo, Ivan ; Ochoa, Melissa 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2005
卷号：46
期号：09
页码：1823-1832
DOI：10.1194/jlr.M500067-JLR200
出版社：American Society for Biochemistry and Molecular Biology
摘要：Hepatic steatosis is commonly present during the developmentof insulin resistance, and it is a clear sign of lipotoxicityattributable in part to an accelerated lipogenesis. There isevidence that a soy protein diet prevents the overexpressionof hepatic sterol-regulatory element binding protein-1 (SREBP-1),decreasing lipid accumulation. Therefore, the aim of the presentwork was to study whether a soy protein diet may prevent thedevelopment of fatty liver through the regulation of transcriptionfactors involved in lipid metabolism in hyperinsulinemic andhyperleptinemic Zucker obese fa/fa rats. Serum and hepatic cholesteroland triglyceride levels, as well as VLDL-triglyceride and LDL-cholesterol,were significantly lower in rats fed soy protein than in ratsfed a casein diet for 160 days. The reduction in hepatic cholesterolwas associated with a low expression of liver X receptor- ${alpha}$ andits target genes, 7- ${alpha}$ hydroxylase and ABCA1. Soy protein alsodecreased the expression of SREBP-1 and several of its targetgenes, FAS, stearoyl-CoA desaturase-1, and ${Delta}$ 5 and ${Delta}$ 6 desaturases,decreasing lipogenesis even in the presence of hyperinsulinemia.Reduction in SREBP-1 was not associated with the presence ofsoy isoflavones. Finally, soy protein reduced SREBP-1 expression in adipocytes,preventing hypertrophy, which also helps prevent the developmentof hepatic lipotoxicity. Supplementary key words steatosis • liver • liver X receptor- ${alpha}$ • sterol-regulatory element binding protein-1