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标题：Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles
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作者：Axel Schlitt ; Mohammad R. Hojjati ; Hans von Gizycki 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2005
卷号：46
期号：02
页码：196-200
DOI：10.1194/jlr.C400011-JLR200
出版社：American Society for Biochemistry and Molecular Biology
摘要：It is known that sphingomyelin (SM) content is higher in apolipoprotein B-containing particles (BLps) than in high density lipoproteins and that BLp levels, including chylomicrons and their remnant particles, are positively related to atherosclerosis. To evaluate the relationship between serum SM and postprandial remnant particle levels, we determined SM, triglyceride (TG), and cholesterol levels in serum and in remnant-like particles (RLPs) before and 3, 5, 7, and 10 h after a high-fat meal in 31 healthy subjects. We found that serum SM, like serum TG, was increased to its maximum 3 h after fat loading and then gradually decreased to basal levels after 10 h. More important, we determined that SM and TG levels in RLPs were parallel. Serum SM was positively correlated with serum TG (P < 0.001), RLP SM (P < 0.001), RLP TG (P < 0.001), and RLP cholesterol (P < 0.001) levels. It is our conclusion that serum SM is a marker for the clearance of RLPs. Abbreviations: apoA-I, apolipoprotein A-I; BLp, apolipoprotein B-containing particle; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; RLP, remnant-like particle; SM, sphingomyelin; TG, triglyceride; TRL, triglyceride-rich lipoprotein
关键词：lipid • lipoprotein • atherosclerosis