文章基本信息

标题：Comparison of bloodstream fatty acid composition from African-American women at gestation, delivery, and postpartum
本地全文：下载
作者：Ken D. Stark ; Skadi Beblo ; Mahadev Murthy 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2005
卷号：46
期号：03
页码：516-525
DOI：10.1194/jlr.M400394-JLR200
出版社：American Society for Biochemistry and Molecular Biology
摘要：Our aim was to examine the docosahexaenoic acid (DHA; 22:6n-3) status of pregnant African-American women reporting to the antenatal clinic at Wayne State University in a longitudinal study design. Fatty acid compositions of plasma and erythrocyte total lipid extracts were determined and food frequency surveys were administered at 24 weeks of gestation, delivery, and 3 months postpartum for participants (n = 157). DHA (mean ± SD) in the estimated total circulating plasma was similar at gestation (384 ± 162 mg) and delivery (372 ± 155 mg) but was significantly lower at 3 months postpartum (178 ± 81 mg). The relative weight percentage of DHA and docosapentaenoic acid n-6 (DPAn-6; 22:5n-6) decreased postpartum, whereas their respective metabolic precursors, eicosapentaenoic acid (EPA; 20:5n-3) and arachidonic acid (AA; 20:4n-6), increased. Similar results were found in erythrocytes. Dietary intake of DHA throughout the study was estimated at 68 ± 75 mg/day. The relative amounts of circulating DHA and DPAn-6 were increased during pregnancy compared with 3 months postpartum, possibly via increased synthesis from EPA and AA. The low dietary intake and blood levels of DHA in this population compared with others may not support optimal fetal DHA accretion and subsequent neural development. Abbreviations: AA, arachidonic acid; DHA, docosahexaenoic acid; DPAn-3, docosapentaenoic acid n-3; DPAn-6, docosapentaenoic acid n-6; EPA, eicosapentaenoic acid; HUFA, highly unsaturated fatty acid
关键词：n-3 fatty acids • omega-3 • docosahexaenoic acid • arachidonic acid • pregnancy • dietary intake • maternal nutrition