摘要：Objective: Primary objective of our study was to assess effect of ‘Metformin’ in sensitizing ovaries for causing optimum follicular maturation (17-18 mm) followed by ovulation after clomiphene therapy, in women with diagnosis of Polycystic ovarian disease.
Methods: Sixty women with ultrasound diagnosis of polycystic ovarian disease were divided into two groups of 30 each. In study group, subjects were started on metformin, while controls received placebo treatment. All women were started on incremental doses of clomiphene citrate. The optimum follicular maturation in two groups was compared. The effect of metformin on other parameters like menstrual cycle pattern, hirsutism and body mass index was assessed.
Results: Optimum follicular maturation followed by ovulation occurred in 27 women in study group as compared to only 16 women in control group (p < .001). The percentage reduction in other parameters like Body Mass Index and LH/FSH ratio was significantly better in metformin group.
Conclusion: Metformin is, simple, safe and effective method of ovarian sensitization to achieve ovulation in resistant cases of polycystic ovarian disease.
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