SCIENCE WRITERS BRIEFING ON LUPUS Reminder/speaker change*/teleconference number**

National Institute of Arthritis and, Musculoskeletal and Skin DiseasesFOR RELEASE, Wednesday, November 5, 1997, Elia Ben-Ari, [email protected] Raab, [email protected]

Thursday, November 6, 1997--12:30 to 2:00 p.m. Natcher Conference Center, Room A, National Institutes of Health, Bethesda, Md. At a Science Writers Briefing on Lupus, held in conjunction with the scientific conference NOVEL PERSPECTIVES ON SYSTEMIC LUPUS ERYTHEMATOSUS: FROM BASIC RESEARCH TO CLINICAL APPLICATIONS, leading experts will describe some of the major questions about lupus that are under study and some of the answers that are emerging. *Ann Marshak-Rothstein, Boston University School of Medicine, Boston, Massachusetts, a conference organizer, will start the briefing with an overview of lupus and of the conference. Briefing speakers will include:

Edward K. Wakeland, Ph.D., Professor, University of Florida College of Medicine, Gainesville, Fl. - Discovering the Genes that Cause Systemic Lupus Erythematosus David Wofsy, M.D., Professor, University of California, San Francisco, Ca. - New Strategies for Treating Systemic Lupus Erythematosus Arthur M. Krieg, M.D., Associate Professor, University of Iowa College of Medicine, Iowa City, Iowa - Whats New in Research into the Triggers for Autoantibody Production Joseph E. Craft, M.D., Professor and Chief of Rheumatology, Yale University School of Medicine, New Haven, Ct. - Mechanisms of Autoantibody Production in Lupus

Systemic lupus erythematosus (SLE or lupus) is the prototypical autoimmune disorder. In lupus, the body produces certain proteins called autoantibodies that contribute to inflammation and tissue injury in the joints, skin, kidneys, heart, lungs, blood vessels, and brain. Lupus affects nine times as many women as men, with minority women having as much as a threefold risk over nonminority women. Lupus is the subject of intense investigation; progress in research and medicine has greatly increased both the length and quality of life for lupus patients. Yet this complex disease still presents many questions and challenges as there is still no known cause or cure.

For more information and to register for the Nov. 6 briefing or the Nov. 6-8 conference contact Connie Raab or Elia Ben-Ari, NIAMS Office of Scientific and Health Communications, ph: (301) 496-8190, e-mail: [email protected] or [email protected]. [The press desk number will be (301) 496-9966.] For your convenience, lunch will be provided during the briefing, courtesy the S.L.E. Foundation, New York, N.Y.

**NOTE: Reporters unable to attend can call in for a teleconference during the briefing at (800) 938-0653. Conference details on the Web: http://www.nih.gov/niams/news/sleconf.htm.

Conference sponsors are: The S.L.E. Foundation; the Lupus Foundation of America; the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); the National Institute of Allergy and Infectious Diseases (NIAID); the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); and the NIH Office of Research on Womens Health.