文章基本信息

标题：Components of acquisition-to-acquisition variance in continuous arterial spin labelling (CASL) imaging
本地全文：下载
作者：Roberto Viviani ; Petra Beschoner ; Hanna Lo 等
期刊名称：BMC Neuroscience
印刷版ISSN：1471-2202
电子版ISSN：1471-2202
出版年度：2010
卷号：11
期号：1
页码：1
DOI：10.1186/1471-2202-11-30
语种：English
出版社：BioMed Central
摘要：Background Images of perfusion estimates obtained with the continuous arterial spin labelling technique are characterized by variation between single acquisitions. Little is known about the spatial determinants of this variation during the acquisition process and their impact on voxel-by-voxel estimates of effects. Results We show here that the spatial patterns of covariance between voxels arising during the acquisition of these images uncover distinct mechanisms through which this variance arises: through variation in global perfusion levels; through the action of large vessels and other, less well characterized, large anatomical structures; and through the effect of noisy areas such as the edges of the brain. Conclusions Knowledge of these covariance patterns is important to experimenters for a correct interpretation of findings, especially for studies where relatively few acquisitions are made.