文章基本信息

标题：ODE, RDE and SDE models of cell cycle dynamics and clustering in yeast
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作者：Erik M. Boczko ; Tomas Gedeon ; Chris C. Stowers 等
期刊名称：Journal of Biological Dynamics
印刷版ISSN：1751-3758
电子版ISSN：1751-3766
出版年度：2010
卷号：4
期号：4
页码：328-345
DOI：10.1080/17513750903288003
出版社：Taylor & Francis
摘要：Biologists have long observed periodic-like oxygen consumption oscillations in yeast populations under certain conditions, and several unsatisfactory explanations for this phenomenon have been proposed. These 'autonomous oscillations' have often appeared with periods that are nearly integer divisors of the calculated doubling time of the culture. We hypothesize that these oscillations could be caused by a form of cell cycle synchronization that we call clustering. We develop some novel ordinary differential equation models of the cell cycle. For these models, and for random and stochastic perturbations, we give both rigorous proofs and simulations showing that both positive and negative growth rate feedback within the cell cycle are possible agents that can cause clustering of populations within the cell cycle. It occurs for a variety of models and for a broad selection of parameter values. These results suggest that the clustering phenomenon is robust and is likely to be observed in nature. Since there are necessarily an integer number of clusters, clustering would lead to periodic-like behaviour with periods that are nearly integer divisors of the period of the cell cycle. Related experiments have shown conclusively that cell cycle clustering occurs in some oscillating yeast cultures.
关键词：autonomous oscillations; cell cycle; budding yeast