文章基本信息

标题：Geometrical study on diseaserelated ncRNAs based on Z-curve method
本地全文：下载
作者：Yan-Ling Yang ; Ji-Hua Wang
期刊名称：Health
印刷版ISSN：1949-4998
电子版ISSN：1949-5005
出版年度：2009
卷号：1
期号：1
页码：24-30
DOI：10.4236/health.2009.11005
出版社：Scientific Research Publishing
摘要：The Z curve is a very useful method for visual-izing and analyzing DNA sequences. It is a three-dimensional space curve that constitutes a unique representation of a given DNA se-quence. It becomes more and more important to study non-coding regions in the recent years. Using Z curve method, 15 disease-related ncRNAs and some snoRNAs and miRNAs sequences are selected from the NONCODE database in this paper, which relate to Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are ob-tained. These features indicate that the ncRNAs sequences playing same roles in the celluar process have almost the same Z-curves. And the base content in these sequences is almost same too.
关键词：Non-CodingRNA; Alzheimer Disease; snoRNA; miRNA; Z-Curve